Table 1.
Demographics and characteristics of patients with and without antibiotic spacers.
| Overall N = 15 |
No Antibiotic Spacer N = 10 |
With Antibiotic Spacer N = 5 |
p-Value | |
|---|---|---|---|---|
| Age (years) | 44 ± 11 | 43 ± 11 | 47.2 ± 11 | 0.459 |
| BMI | 23.1 ± 5.3 | 21.3 ± 4.7 | 26.5 ± 5.1 | 0.070 |
| Gender (female) | 9 (60%) | 6 (60%) | 3 (60%) | 1.000 |
| Active injection drug use at time of initial hospitalization | 13 (87%) | 10 (100%) | 3 (60%) | 0.095 |
| Chronic HCV infection | 9 (60%) | 5 (50%) | 4 (80%) | 0.580 |
| HIV infection | 3 (20%) | 1 (10%) | 2 (40%) | 0.242 |
| History of endocarditis | 3 (20%) | 2 (20%) | 1 (20%) | 1.000 |
| Active tobacco use | 15 (100%) | 10 (100%) | 5 (100%) | 1.000 |
| Met SIRS criteria on presentation | 4 (27%) | 3 (30%) | 1 (20%) | 1.000 |
| Stable housing | 7 (47%) | 4 (40%) | 3 (60%) | 0.608 |
| Other diagnosed psychiatric disorder, other than SUD | 6 (40%) | 6 (60%) | 0 (0%) | 0.044 |
| Paraplegic | 2 (13%) | 2 (20%) | 0 (0%) | 0.524 |
| Inpatient length of stay (days) | 9 (9–24) | 20 (11–46) | 13 (9–16) | 0.297 |
| Overall follow-up (months) | 25 ± 20 | 24 ± 22.4 | 27 ± 17 | 0.765 |
| Follow-up excluding deceased (months) | 32 ± 20 | 32 ± 24 | 31 ± 17 | 0.960 |
| Mortality | 4 (27%) | 3 (30%) | 1 (20%) | 1.000 |
| Time to mortality (days) | 78 (60–227) | 70 (50–85) | 369 [369] | 0.180 |
BMI: body mass index. HCV: hepatitis C virus. HIV: human immunodeficiency virus. SIRS: systemic inflammatory response syndrome. Criteria per Sepsis-3 consensus definitions. SUD: substance use disorder. Continuous values are reported as mean ± standard deviation or median [interquartile range] based on normality as determined by the Shapiro–Wilk test. p-values for continuous variables were determined by the Mann–Whitney U-test or t-tests with equal or unequal variance as appropriate. Categorical variables are reported as N (Percent). p-values for categorical variables were determined by Fisher’s exact test [20]. Bold-face indicates statistical significance.