Table 6.
Pathways that were significantly enriched using MetaboAnalyst.
| Pathway | Total | Exp | Hits | Raw p-Value | FDR |
|---|---|---|---|---|---|
| Pentose phosphate pathway | 22 | 0.64 | 7 | 1.28 × 10−6 | 0.00011 |
| Arginine biosynthesis | 14 | 0.41 | 5 | 2.65 × 10−5 | 0.00111 |
| Glycolysis/Gluconeogenesis | 26 | 0.75 | 5 | 0.00067 | 0.0188 |
| Alanine, aspartate, and glutamate metabolism | 28 | 0.81 | 5 | 0.00096 | 0.0202 |
| Butanoate metabolism | 15 | 0.43 | 3 | 0.00805 | 0.113 |
| Nicotinate and nicotinamide metabolism | 15 | 0.43 | 3 | 0.00805 | 0.113 |
Abbreviations: Total: number of metabolites in the pathway. Exp: expected number of input metabolites that would be in the pathway by random chance. Hits: metabolites significantly different between delirium and control groups, i.e., input metabolites, that are in the pathway. FDR: False discovery rate based on the Benjamini–Hochberg method [37].