Table 3.
Networks of the biological processes (GO) or pathways (Reactome) with FDR < 0.05 obtained by including all the 91 proteins listed in Table 2. GO and/or Reactome entries, FDR, and implicated proteins are reported. When commonly used, short names are indicated.
| Biological Processes/ Pathways |
GO/Reactome Entry (FDR) | Proteins |
|---|---|---|
| Degradation of the ECM |
REAC:R-HSA-3560782 (0.02) |
Decorin; lumican; mimecan; basigin; collagen alpha-2(IV) chain; FN; NID-1, tryptase-1 |
| ECM proteoglycans |
REAC:R-HSA-3000178 (0.01) |
Decorin; lumican; HPLPN1; collagen alpha-2(IV) chain; FN |
| ECM organization |
REAC:R-HSA-1474244 (0.003) |
Decorin; lumican; HPLPN1; basigin; collagen alpha-2(IV) chain; FN; tryptase-1; 4-PH alpha-1; NID-1; serpin H1 |
| Aerobic respiration/ Cellular respiration |
GO:0009060/GO:0045333 (0.02) |
PDHE1-B; OGDH-E1; ATP synthase subunit O; cytochrome c oxidase subunit 2; cytochrome c oxidase sub. 5B; DLST; NDUFV1 |
| Generation of precursor metabolites and energy |
GO:0006091 (0.02) |
PDHE1-B; OGDH-E1; DLST; ATP synthase subunit O; cytochrome c oxidase subunit 2; cytochrome c oxidase sub. 5B; NDUFV1; PGM-1; ADH1C; ADH1B |
| Citric acid cycle and respiratory electron transport |
REAC:R-HSA-1428517 (0.003) |
PDHE1-B; OGDH-E1; DLST; ATP synthase subunit O; cytochrome c oxidase subunit 2; cytochrome c oxidase sub. 5B; NDUFV1; basigin |
| 2-oxoglutarate metabolic process |
GO:0006103 (0.02) |
OGDH-E1; DLST; cAspAT |
| Histone succinylation/ Protein succinylation |
GO:0106077/GO:0018335 (0.03)/(0.04) |
OGDH-E1; DLST |
| Metabolism |
REAC:R-HSA-1430728 (0.01) |
PDHE1-B; OGDH-E1; DLST; cAspAT; ATP synthase subunit O; cytochrome c oxidase subunit 2; cytochrome c oxidase sub. 5B; NDUFV1; PGM-1; GPDH-C; ETHE1; ADH1C; ADH1B; CEH; CE-2; A-FABP; aldo-keto reductase 1B1; UDP-GlcDH; decorin; lumican; mimecan; CA-II; basigin; Galphai2; PLD3; N-WASP |
| Neutrophil chemotaxis | GO:0030593 (0.03) | S100A8; S100A9; Gal-3; PBP; basigin |
| Leukocyte chemotaxis/ Myeloid leukocyte migration |
GO:0030595/GO:0097529 (0.02) |
S100A8; S100A9; Gal-3; PBP; basigin; CgA; MIF |
| Leuckocyte migration | GO:0050900 (0.04) | S100A8; S100A9; Gal-3; PBP; basigin; CgA; MIF; N-WASP |
| Neutrophil aggregation | GO:0070488 (0.02) | S100A8; S100A9 |
| Metal sequestration by antimicrobial proteins |
REAC:R-HSA-6799990 (0.002) |
Lactotransferrin; S100A8; S100A9 |
| Sequestering of zinc ion | GO:0032119 (0.02) | S100A8; S100A9 |