Table 3.
Characteristics a of NSCLC patients in relation to the presence of PD-L1 mutations.
| [ALL] | PD-L1: Wild-Type |
PD-L1: Mutated | p-Value | N b | |
|---|---|---|---|---|---|
| N = 67 | N = 42 | N = 25 | |||
| Age | 69.0 [63.0; 74.0] | 69.0 [63.0; 71.8] | 68.0 [64.0; 74.0] | 0.68 | 67 |
| Gender: | 0.16 | 67 | |||
| F | 14 (20.9%) | 6 (14.3%) | 8 (32.0%) | ||
| M | 53 (79.1%) | 36 (85.7%) | 17 (68.0%) | ||
| Histological type | 0.64 | 67 | |||
| adenocarcinoma | 31 (46.3%) | 18 (42.9%) | 13 (52.0%) | ||
| squamous cell carcinoma | 36 (53.7%) | 24 (57.1%) | 12 (48.0%) | ||
| Stage: | 0.86 | 52 | |||
| 2 | 1 (1.92%) | 1 (3.03%) | 0 (0.00%) | ||
| 3 | 28 (53.8%) | 17 (51.5%) | 11 (57.9%) | ||
| 4 | 23 (44.2%) | 15 (45.5%) | 8 (42.1%) | ||
| Lymphocytes, ×103/µL | 1.49 [1.08; 2.06] | 1.52 [1.12; 1.99] | 1.40 [1.07; 2.39] | 0.87 | 60 |
| Neutrophils, ×103/µL | 7.78 [5.89; 10.4] | 8.15 [6.80; 10.5] | 6.28 [5.24; 9.46] | 0.09 | 60 |
| Platelets, ×103/µL | 338 [276; 428] | 60 [279; 442] | 322 [256; 361] | 0.26 | 60 |
| C-reactive protein, mg/L | 45.3 [15.3; 134] | 76.7 [32.6; 140] | 22.7 [10.4; 40.3] | 0.03 | 48 |
| Hemoglobin, g/dL | 12.6 [11.2; 13.7] | 12.2 [10.8; 14.0] | 13.1 [11.9; 13.7] | 0.28 | 57 |
| Smoking, packs/year | 39.0 [24.8; 50.0] | 38.0 [24.5; 47.5] | 40.0 [30.0; 60.0] | 0.54 | 64 |
| COPD: | 1 | 66 | |||
| no | 21 (31.8%) | 13 (31.7%) | 8 (32.0%) | ||
| yes | 45 (68.2%) | 28 (68.3%) | 17 (68.0%) | ||
| BMI, kg/m2 | 24.5 [19.9; 26.6] | 23.6 [19.5; 25.3] | 25.8 [24.6; 28.0] | 0.08 | 35 |
| NLR | 5.15 [3.18; 8.15] | 5.30 [3.45; 8.95] | 4.50 [2.85; 5.92] | 0.23 | 60 |
| PLR | 220 [151; 340] | 227 [159; 362] | 198 [141; 304] | 0.31 | 60 |
a Values are presented as numbers (percentages) for categorical variables and medians [interquartile range] for numerical variables. b Number of observations for a given variable. COPD = chronic obstructive pulmonary disease.