Figure 5.

Networks among germline mutated genes. Three independent networks involving mutated genes were identified in different cases. Network nodes (colored spheres) represent proteins (empty nodes = proteins of unknown 3D structure; filled nodes = a 3D structure is known or predicted). Straight lines connecting the nodes represent protein–protein associations (blue lines = known interactions from curated databases; purple lines = known experimentally determined interactions; dark green lines = predicted interactions such as neighborhood gene; light green = predicted interactions by text mining; black lines = co-expression).