Table 3.
(a) Comparison of anthropometric Z-scores before and after treatment based on motor functions and SMA types. (b) Comparison of pre- and post-study motor functions based on malnutrition status.
| (a) | ||||||
|---|---|---|---|---|---|---|
| BMI2/BMI1 | HFA2/HFA1 | |||||
| ≥3%, n = 11 | <3%, n = 23 | p | ≥3%, n = 18 | <3%, n = 16 | p | |
| Hammersmith | ||||||
| PtS | 37.0 (22.5) | 34.7 (17.9) | 0.809 | 34.9 (19.0) | 28.0 (23.8, 58.8) | 0.717 |
| AtS | 37.4 (22.1) | 35.8 (19.2) | 0.873 | 36.5 (20.4) | 29.0 (23, 58.8) | 0.921 |
| P *, n | 0.178, 5 | 0.242, 17 | 0.226, 12 | 0.206, 10 | ||
| CHOP-INTEND | ||||||
| PtS | 42.3 (16.4) | 38.4 (25.8) | 0.765 | 36.4 (25.3) | 44.0 (16.4) | 0.561 |
| AtS | 47.8 (17.3) | 39.4 (25.4) | 0.529 | 37.4 (24.8) | 49.5 (16.7) | 0.360 |
| P *, n | 0.299, 6 | 0.034, 5 | 0.034, 5 | 0.299, 6 | ||
| SMA type 1 | 8 (53.3) | 7 (46.7) | 0.028 | 6 (40.9) | 9 (60.0) | 0.100 |
| SMA type 2 | 2 (20.0) | 8 (80.0) | 5 (50.0) | 5 (50.0) | ||
| SMA type 3 | 1 (11.1) | 8 (88.9) | 7 (77.8) | 2 (22.2) | ||
| ( b) | ||||||
| Hammersmith | CHOP-INTEND | |||||
| PtS | AtS | P *, n | PtS | AtS | P *, n | |
|
BMI z-score ≥−1
(no malnutrition) |
34.9 (16.5) | 32.9 (16.7) | 0.295, 17 | 41.6 (16.6) | 45.2 (15.0) | 0.052, 5 |
|
BMI z-score <−1 and >−2
(mild Malnutrition) |
29.0 (30.3) | 36.6 (26.4) | 0.083, 3 | 58.5 (18.3, 62) | NA | 0.705, 4 |
|
BMI z-score ≤−2
(moderate–severe malnutrition) |
46.5 (24.8) | 50.7 (18.2) | 0.317, 2 | 26.5 (12.0) | 42.6 (27.9) | 0.180, 2 |
| P | 0.491 | 0.118 | 0.624 | 0.860 | ||
(a) BMI, body mass index; HFA, height for age; PtS, prior to study; AtS, after the study; CHOP-INTEND, Children’s Hospital of Philadelphia infant test of neuromuscular disorders; countable data presented as number (percent); continuous normal data presented as mean (standard deviation,) and skewed data presented as median (first quartile, third quartile); significant values are written in bold; values with insufficient sample size are underlined. Student’s t- and paired t-tests are used for normal; Mann–Whitney U and Wilcoxon tests are used for skewed data; Linear-linear association test is used for ordinal Fisher’s exact test is used for nominal categories; *, PtS versus AtS. (b) PtS, prior to study for both BMI and survey scores; AtS, after the study for both BMI and survey scores; BMI, body mass index; CHOP-INTEND, Children’s Hospital of Philadelphia infant test of neuromuscular disorders; continuous normal data presented as mean (standard deviation), and skewed data presented as median (first quartile, third quartile); significant values are written in bold; values with insufficient sample size are underlined; Student’s t- and paired t-tests are used for normal, Mann–Whitney U and Wilcoxon tests are used for skewed data; *, PtS versus AtS based on PtS BMI score sub-groups.