Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Aug 8;14(8):969. doi: 10.3390/biom14080969

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Identification of significant genes in CCA. (a) The Venn diagram represents 80 upregulated proteins from the proteomic analysis and 25 upregulated genes in CCA tissue compared to normal tissue. (b) Heatmap analysis displaying the expression of 25 overlapping genes that were significantly upregulated in CCA patients’ tissues based on TCGA data (left) and proteomics data (right). (c) PPI analysis of the 25 upregulated genes via STRING. (d) Box plot showing the mRNA expression of six selected genes (a focused network) in CCA patients’ tissues (red box) vs. normal tissues (grey box) based on TCGA data. Significant differences between groups are indicated by * p < 0.05. (e) The mRNA expression of six selected genes verified by RT-qPCR in KKU-213A, KKU-213FR, and KKU-213GR. Significant differences between the KKU-213A and KKU-213FR groups, as well as between the KKU-213A and KKU-213GR groups, are indicated by *** p < 0.001.