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LRR organization of NLRP3. (A) Each exon code for 2 completes LRR motifs alternating 28 or 29 amino acids. NLRP3 is composed of 11 LRRs that are characterized by a high leucine (blue) and cysteine (red) content and a consensus sequence. (B) The structure of the LRR domain with each LLR repeat is highlighted. (C) Structure of the LRR domain with leucine in blue and cysteine in red. (PDB model: 7PZC).
