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Transduction model of by AAV vectors via binding AAV to cell surface receptor. AAV was internalized into cytoplasm of cell by endosomal trafficking via interaction with AAV receptor (AAVR). The internalized AAVs entry into nucleus through endosomal escape, and then the AAVs within the nucleus release viral single-stranded DNA via uncoating, which forms nucleoprotein filament complex due to transcription.
