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Cladosporol A actions regulating cell proliferation in colon cancer-derived cells. (1) Increase in p21waf1/cip1 transcription mediated by PPARγ and Sp1. (2) Down-regulation of cyclin D1, cyclin E, CDK2, and CDK4 expression and their phosphorylation activities. (3) Down-regulation of the β-catenin-dependent target gene transcription, i.e., cyclin D1 and c-myc. (4) PPARγ-dependent increase in E-cadherin mRNA transcription. (5) Proteasomal degradation of PPARγ and β-catenin.
