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. 2024 Jul 23;46(8):7846–7861. doi: 10.3390/cimb46080465

Figure 1.

Figure 1

Summary of four plausible hypotheses for the description of CD4+ T cells in ALS. The SWITCH hypothesis assumes that Treg loses its capacity to suppress Th17 in the later stages of the disease. Hypothesis 2 underscores the effect of the aging of memory CD4+ T cells on the progression of ALS. Hypothesis 3 focuses on the role of specific, less-known CD4+ T cells that can harm neurons, while hypothesis 4 underlines the effect of γδ CD4+ T cells in terms of inhibiting the anti-inflammatory effects of CD4+ Tregs.