Table 3.
Association of six-minute walk performance with lower extremity events with and without adjustment for ABI.
| Tertile 1 HR (95% CI) (21–326 m) n = 123 |
p-value | Tertile 2 HR (95% CI) (327–412 m) n = 124 |
p-value | Tertile 3 HR (95% CI) (412–701 m) n = 122 |
|
|---|---|---|---|---|---|
| Model 1 | |||||
| All lower extremity outcomes | 1.59 (1.09, 2.33) n = 66 |
0.0166 | 1.13 (0.77, 1.65) n = 55 |
0.54 | Ref. n = 56 |
| Model 2 | |||||
| All lower extremity outcomes | 1.74 (1.17, 2.60) |
0.0067 | 1.16 (0.79, 1.70) |
0.44 | Ref. |
| Model 1 | |||||
| Lower extremity revascularization | 1.89 (0.96, 3.71) n = 21 |
0.06 | 1.48 (0.77, 2.86) n = 20 |
0.24 | Ref. n = 17 |
| Model 2 | |||||
| Lower extremity revascularization | 1.96 (0.96, 4.01) |
0.06 | 1.50 (0.77, 2.90) |
0.23 | Ref. |
| Model 1 | |||||
| ABI decline > 15%a | 1.51 (0.98, 2.32) n = 52 |
0.06 | 1.01 (0.65, 1.55) n = 41 |
0.97 | Ref. n = 44 |
| Model 2 | |||||
| ABI decline > 15%a | 1.77 (1.12, 2.78) |
0.0136 | 1.08 (0.70, 1.68) |
0.72 | Ref. |
| Model 1 | |||||
| Critical limb ischemia or amputation | 5.52 (0.89, 34.23) n = 7 |
0.07 | 2.53 (0.38, 17.06) n = 4 |
0.34 | Ref. n = 2 |
| Model 2 | |||||
| Critical limb ischemia or amputation | 4.78 (0.70, 32.67) |
0.11 | 2.45 (0.36, 16.69) |
0.36 | Ref. |
Model 1 adjusteding for age, sex, race, BMI, smoking, comorbidities, and statin use. Model 2 adjusted for variables in Model 1 + ABI.
a
Four people are not included in the analyses for ABI decline > 15%: one in tertile 1, two in tertile 2, and one in tertile 3.
ABI, ankle–brachial index; BMI, body mass index; HR, hazard ratio.