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. 2024 Jul 24;15(8):975. doi: 10.3390/genes15080975

Table 1.

Differentially expressed genes (DEGs) in older male 14D HU group relative to age- and sex- matched NL control group. DEGs were selected using an adj p-value < 0.05 at a log2 fold change cut-off > 0.3 or <−0.3. Total DEGs: 125 (48 upregulated and 77 downregulated).

DEGs Log2 FC p adj Gene Name
Actg2 −2.15 0.0241 Actin, γ 2, smooth muscle, enteric
Adhfe1 −0.53 0.0003 Alcohol dehydrogenase, iron-containing, 1
Alox5ap 0.58 0.0454 Arachidonate 5-lipoxygenase activating protein
Aplnr −0.41 0.0457 Apelin receptor
Aqp7 −0.77 0.0007 Aquaporin 7
Arl11 0.79 0.0357 ADP-ribosylation factor-like GTPase 11
Arntl −1.92 1.77 × 10−12 Aryl hydrocarbon receptor nuclear translocator-like
Asb2 −0.32 0.0002 Ankyrin repeat and SOCS box-containing 2
Atp2a1 −0.77 0.0284 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Atp4a −1.69 0.0075 ATPase H+/K+ transporting subunit α
Bcat2 −0.40 0.0038 Branched chain amino acid transaminase 2
Bckdha −0.40 0.0083 Branched chain ketoacid dehydrogenase E1, α polypeptide
Bcl6b −0.61 0.0055 BCL6B, transcription repressor
C1qa 0.57 0.0483 Complement C1q A chain
C1qb 0.74 0.0005 Complement C1q B chain
C1qc 0.69 0.0007 Complement C1q C chain
C5ar1 0.61 0.0483 Complement C5a receptor 1
Car4 −1.15 0.0017 Carbonic anhydrase 4
Cd14 0.67 0.0314 CD14 molecule
Cd163 0.92 0.0004 CD163 molecule
Cd44 0.33 0.0353 CD44 molecule
Cd68 0.99 0.0059 CD68 molecule
Cd93 −0.42 0.0065 CD93 molecule
Cdkn1a −0.75 0.0011 Cyclin-dependent kinase inhibitor 1A
Cited4 −0.52 0.0296 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
Clec4a1 0.86 0.0121 C-type lectin domain family 4, member A1
Clock −0.44 0.0002 Clock circadian regulator
Clu 0.44 0.0055 Clusterin
Col5a3 −0.66 0.0280 Collagen type V α 3 chain
Crispld2 −0.45 0.0234 Cysteine-rich secretory protein LCCL domain-containing 2
Csf1r 0.51 0.0111 Colony stimulating factor 1 receptor
Dkk3 −0.30 0.0351 Dickkopf WNT signaling pathway inhibitor 3
Dot1l −0.44 0.0190 DOT1-like histone lysine methyltransferase
Ecrg4 −1.27 0.0299 ECRG4 augurin precursor
Eepd1 −0.44 0.0007 Endonuclease/exonuclease/phosphatase family domain-containing 1
Ephx1 0.84 0.0007 Epoxide hydrolase 1
Exoc4 0.35 0.0073 Exocyst complex component 4
F5 0.86 0.0345 Coagulation factor V
Fabp3 −0.41 1.03 × 10−5 Fatty acid-binding protein 3
Fam160a1 −0.51 0.0369 Family with sequence similarity 160, member A1
Fam220a −0.40 0.0010 Family with sequence similarity 220, member A
Fam26e −0.67 0.0235 Calcium homeostasis modulator family member 5
Fcgr2b 0.98 0.0314 Fc fragment of IgG receptor IIb
Fcna 0.63 0.0015 Ficolin A
Fhl2 −0.51 0.0121 Four and a half LIM domains 2
Gnb3 −0.47 0.0093 G protein subunit β 3
Gng2 0.47 0.0457 G protein subunit γ 2
Gpsm1 −0.42 0.0063 G-protein signaling modulator 1
Grip2 −1.46 0.0022 Glutamate receptor interacting protein 2
Gsn −0.49 0.0008 Gelsolin
Gstz1 −0.69 0.0006 Glutathione S-transferase zeta 1
Hadh −0.37 1.60 × 10−5 Hydroxyacyl-CoA dehydrogenase
Heyl −0.31 0.0105 Hairy/enhancer-of-split related with YRPW motif-like
Hspa5 −0.34 0.0456 Heat shock protein family A member 5
Inha 0.71 0.0345 Inhibin subunit α
Ispd −0.44 0.0190 Isoprenoid synthase domain-containing
Itga6 −0.36 0.0011 Integrin subunit α 6
Itgam 0.90 0.0061 Integrin subunit α M
Itgb2 0.80 0.0108 Integrin subunit β 2
Kank1 −0.39 0.0307 KN motif and ankyrin repeat domains 1
Kcnma1 −2.16 0.0008 Potassium large conductance calcium-activated channel, subfamily M, α member 1
Laptm5 0.50 0.0117 Lysosomal protein transmembrane 5
Lbh −0.38 0.0226 Limb bud and heart development
Lcp1 0.42 0.0162 Lymphocyte cytosolic protein 1
Leo1 −0.34 0.0295 LEO1 homolog, Paf1/RNA polymerase II complex component
Lgals3 0.81 0.0077 Galectin 3
Lilrb3l 0.82 0.0435 Leukocyte immunoglobulin-like receptor subfamily B member 3-like
Limd1 −0.48 0.0015 LIM domain-containing 1
Lingo4 −0.55 0.0142 Leucine-rich repeat and Ig domain-containing 4
Map3k7cl −0.66 0.0369 MAP3K7 C-terminal-like
Mill1 −1.78 0.0007 MHC I-like leukocyte 1
Mrc1 0.70 0.0105 Mannose receptor, C type 1
Mtfp1 −0.33 0.0250 Mitochondrial fission process 1
Mtus1 −0.30 0.0077 Mitochondrial tumor suppressor 1
Mx2 −0.45 0.0004 MX dynamin-like GTPase 2
Myh11 −1.46 0.0483 Myosin heavy chain 11
Myo5b −0.46 0.0261 Myosin Vb
Myom2 −0.85 1.53 × 10−14 Myomesin 2
Nckap1l 0.72 0.0091 NCK associated protein 1-like
Npas2 −1.43 1.51 × 10−6 Neuronal PAS domain protein 2
Nrp2 −0.31 0.0457 Neuropilin 2
Ntsr1 1.01 0.0405 Neurotensin receptor 1
Nudt4 0.37 0.0073 Nudix hydrolase 4
P2rx4 0.42 0.0483 Purinergic receptor P2X 4
Paqr6 −0.57 0.0250 Progestin and adipoQ receptor family member 6
Per2 0.84 1.29 × 10−9 Period circadian regulator 2
Per3 1.25 0.0226 Period circadian regulator 3
Phlda1 −0.65 0.0420 Pleckstrin homology-like domain, family A, member 1
Pi16 −0.58 0.0215 Peptidase inhibitor 16
Pik3ip1 0.43 0.0043 Phosphoinositide-3-kinase interacting protein 1
Ppp1r14c −0.34 0.0405 Protein phosphatase 1, regulatory (inhibitor) subunit 14c
Ppp1r3c −0.41 0.0065 Protein phosphatase 1, regulatory subunit 3C
Rapgef5 0.31 0.0451 Rap guanine nucleotide exchange factor (GEF) 5
Rasd2 −0.77 0.0091 RASD family, member 2
Rasl11b −0.59 0.0105 RAS-like family 11 member B
Rcan1 −0.63 0.0005 Regulator of calcineurin 1
Rhobtb1 0.82 2.92 × 10−9 Rho-related BTB domain-containing 1
Rhoj −0.41 0.0210 Ras homolog family member J
Rimbp2 −0.62 0.0025 RIMS-binding protein 2
Rpl3 0.46 0.0120 Ribosomal protein L3
Rpl3l −0.62 0.0004 Ribosomal protein L3-like
S100a10 0.37 0.0154 S100 calcium-binding protein A10
S100a4 0.84 1.60 5 S100 calcium-binding protein A4
Slc38a2 −0.31 0.0015 Solute carrier family 38, member 2
Slc41a3 −0.87 5.13 × 10−7 Solute carrier family 41, member 3
Slc8a2 −1.94 0.0454 Solute carrier family 8 member A2
Smyd2 −0.38 0.0483 SET and MYND domain-containing 2
Sparcl1 −0.40 0.0015 SPARC-like 1
Srebf1 −0.32 0.0166 Sterol regulatory element-binding transcription factor 1
Stxbp1 0.34 0.0038 Syntaxin-binding protein 1
Tef 0.74 0.0002 TEF, PAR bZIP transcription factor
Tf 0.64 0.0295 Transferrin
Tfrc −0.51 0.0142 Transferrin receptor
Tgm1 1.11 0.0084 Transglutaminase 1
Tlr8 1.06 0.0053 Toll-like receptor 8
Tmem176b 0.31 0.0197 Transmembrane protein 176B
Tmem179 −0.51 0.0091 Transmembrane protein 179
Tp53i11 −0.42 0.0051 Tumor protein p53 inducible protein 11
Tpsb2 −0.78 0.0339 Tryptase β 2
Trim16 −0.36 0.0357 Tripartite motif-containing 16
Tspan18 −0.57 0.0084 Tetraspanin 18
Tut1 0.51 0.0277 Terminal uridylyl transferase 1, U6 snRNA-specific
Tyrobp 0.50 0.0365 Transmembrane immune signaling adaptor Tyrobp
Ucp3 −1.69 4.13 × 10−5 Uncoupling protein 3
Wee1 0.47 0.0357 WEE1 G2 checkpoint kinase