Table 3.

Select human diseases associated with a subset of DEGs in this study. The last column indicates the number of DEGs that overlap with the known set of genes associated with human disease. Refer to Table S3 for full list. CVD: Cardiovascular disease.

Classification	Disease	FDR	No. of DEGs
CVD	Libman–Sacks disease (nonbacterial thrombotic endocarditis)	0.0059	4
CVD	Coronary restenosis (is_implicated_in)	0.0150	2
CVD	Abdominal aortic aneurysm (is_marker_for)	0.0208	2
CVD	Myocardial infarction (is_implicated_in)	0.0208	4
CVD	Posterior choroidal artery infarction	0.0218	2
CVD	Peripheral arterial disease	0.0330	3
CVD	Hypertension (is_implicated_in)	0.0336	4
Immune disorder	C1q deficiency	4.50 × 10−5	3
Immune disorder	Lupus erythematosus, systemic	0.0013	5
Immune disorder	Complement deficiency disease	0.0125	3
Immune disorder	Systemic lupus erythematosus (implicated_via_orthology)	0.0200	3
Metabolic disease	Obesity	2.83 × 10−9	13
Metabolic disease	Endogenous hyperinsulinism	0.0007	4
Metabolic disease	Exogenous hyperinsulinism	0.0007	4
Metabolic disease	Compensatory hyperinsulinemia	0.0007	4
Metabolic disease	Insulin resistance	0.0007	5
Metabolic disease	Insulin sensitivity	0.0007	5
Metabolic disease	Hyperinsulinism	0.0007	4
Metabolic disease	Metabolic syndrome	0.0330	5
Neurovascular disease	Stroke, ischemic	0.0078	2
Neurovascular disease	Ischemic stroke	0.0078	2
Neurovascular disease	Brain ischemia (biomarker_via_orthology)	0.0218	4
Neurovascular disease	Cerebral infarction, left hemisphere	0.0218	2
Neurovascular disease	Anterior choroidal artery infarction	0.0218	2
Neurovascular disease	Cerebral infarction, right hemisphere	0.0218	2
Neurovascular disease	Subcortical infarction	0.0218	2
Neurovascular disease	Cerebral infarction	0.0218	2
Cancer, hematological	Myeloid leukemia, chronic	0.0008	4
Cancer, hematological	Acute myeloid leukemia, m1	0.0014	6
Cancer, hematological	Acute myeloid leukemia (aml-m2)	0.0014	6
Cancer, hematological	Leukemia, myelocytic, acute	0.0057	6
Cancer, hematological	Adult t-cell leukemia/lymphoma (is_marker_for)	0.0181	2
Cancer, hematological	Acute promyelocytic leukemia	0.0218	3
Cancer, hematological	Hematologic neoplasms	0.0258	2
Sleeping disorder	Seasonal affective disorder	0.0002	4
Sleeping disorder	Advanced sleep phase syndrome, familial	0.0042	2
Sleeping disorder	Advanced sleep phase syndrome (is_implicated_in)	0.0059	2