Table 4.
Select pharmacologicals associated with a subset of DEGs in this study. The list contains current and discontinued drugs. Refer to Table S4 for the full list of pharmacologicals and associated DEGs. CVD: cardiovascular disease, HIV: human immunodeficiency virus, MS: multiple sclerosis.
| Drug | Use | No. of DEGs | FDR |
|---|---|---|---|
| Atorvastatin calcium | Anti-CVD, antihypercholesterolemic | 7 | 0.0069 |
| Cerivastatin | Anti-CVD, antihypercholesterolemic | 3 | 0.0371 |
| Simvastatin | Anti-CVD, antihypercholesterolemic | 14 | 0.0007 |
| Abciximab | Antithrombotic | 4 | 0.0002 |
| Losartan | Antihypertensive, angiotensin receptor blocker | 6 | 0.0190 |
| Valsartan | Antihypertensive, angiotensin receptor blocker | 6 | 0.0051 |
| Hydrochlorothiazide | Antihypertensive, diuretic | 2 | 0.0305 |
| Isoproterenol | Anti-bradycardia, non-selective β-adrenergic receptor agonist | 24 | 1.043 × 10−6 |
| Muraglitazar | Antidiabetic | 11 | 0.0037 |
| Rosiglitazone | Antidiabetic | 27 | 3.669 × 10−5 |
| Tesaglitazar | Antidiabetic | 12 | 0.0025 |
| Troglitazone | Antidiabetic | 17 | 0.0305 |
| Basiliximab | Immune suppressor, organ transplant | 4 | 0.0002 |
| Muromonab | Immune suppressor, organ transplant | 4 | 0.0003 |
| Efalizumab | Anti-auto immune disease, anti-psoriasis | 4 | 0.0001 |
| Etanercept | Anti-auto immune disease, anti-psoriasis | 4 | 0.0002 |
| Alefacept | Anti-auto immune disease, psoriasis | 4 | 0.0001 |
| Rituximab | Anti-Rheumatoid arthritis | 4 | 0.0001 |
| Adalimumab | Anti-rheumatoid arthritis, anti-Crohn’s disease, anti-psoriasis | 4 | 0.0001 |
| Palivizumab | Antiviral | 4 | 9.213 × 10−5 |
| Nevirapine | Anti-HIV | 5 | 0.0246 |
| Daclizumab | Anti-MS | 4 | 0.0001 |
| Natalizumab | Anti-MS | 4 | 0.0001 |
| Apomab | Anticancer | 4 | 0.0048 |
| Bevacizumab | Anticancer | 4 | 0.0001 |
| Cetuximab | Anticancer | 4 | 0.0001 |
| Ibritumomab | Anticancer | 4 | 0.0001 |
| temozolomide | Anticancer, brain | 6 | 0.0414 |
| Trastuzumab | Anticancer, breast | 4 | 0.0002 |
| Alemtuzumab | Anticancer, leukemia | 4 | 0.0001 |
| Dasatinib | Anticancer, leukemia | 12 | 0.0018 |
| Doxorubicin | Anticancer, leukemia | 32 | 9.174 × 10−7 |
| Gemtuzumab ozogamicin | Anticancer, leukemia | 4 | 0.0001 |
| Tositumomab | Anti-non-Hodgkins lymphoma | 4 | 0.0001 |
| Clodronate | Antiosteoporotic | 5 | 0.0039 |
| Raloxifene Hydrochloride | Antiosteoporotic | 13 | 0.0305 |
| Zoledronic acid | Antiosteoporotic | 19 | 0.0198 |
| Melatonin | Sleeping aid | 11 | 5.279 × 10−5 |