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. 2024 Aug 8;25(16):8655. doi: 10.3390/ijms25168655

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effect of SBL treatment on the diversity and composition of gut microbiota (n = 6). (A) Alpha diversity includes the Chao1 index, Shannon indices, and Observed OTUS. (B) The cladogram showed significant changes in gut microbiota between the healthy control group and the HDM group as well as between the HDM group and the SBL-treated group. (C) LEfSe results comparing the fecal microbiota between the healthy control and HDM groups, with a linear discriminant analysis (LDA) score of greater than +3.0, and between the HDM and SBL-treated groups, with an LDA score of greater than +3.0, as represented by the length of the bar. * p < 0.05. Control: healthy control; HDM: HDM-induced AR mice; SBL: SBL oral treatment on HDM-induced AR mice.