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. 2024 Aug 8;25(16):8655. doi: 10.3390/ijms25168655

Figure 8.

Figure 8

The alleviation of the IL-6 level in the NALF and suppression of the Erk and PI3K/AKT signaling in nasal mucosa upon SBL treatment. (A)The levels of inflammatory cytokines IL-6 in the NALF were determined using CBA with flow cytometry (BD FACSVia flow cytometer); (B,C) protein expression levels of the expression of signaling molecules (p-AKT, AKT, p-Erk1/2, Erk1/2, PI3K, and Smad3) in the nasal mucosa of different groups were presented in a Western blot. The semi-quantitative analysis of (D) p-AKT, (E) AKT, (F) p-Erk1/2, (G) Erk1/2, (H) Smad3, and (I) PI3K levels based on grey-scale values of GAPDH. Results were presented with mean + SEM. * p < 0.05, ** p < 0.01, *** p < 0.001. Control: healthy control; HDM: HDM-induced AR mice; SBL: SBL oral treatment on HDM-induced AR mice.