Table 1.
ASOs used in this study.
| Name | ASO Sequence 5′ --> 3′ | Length (bp) | Target COL3A1 Exon |
|---|---|---|---|
| COL3A1_H10A(−13+12) | ACCUUUGAUACCCUAAAAAUAAUGA | 25 | 10 |
| COL3A1_H10A(+15+39) | ACCAGGGAAUCCAGGUAUCCCAGCU | 25 | 10 |
| COL3A1_H10D(+12−13) | AAACUCUACUUACUCUGUGUCCUUU | 25 | 10 |
| COL3A1_H15A(−43−19) | AUUUCAAGAGCUCUUUUUCAACUAA | 25 | 15 |
| COL3A1_H15A(−15+10) | CAGGAGGGCCCCGAAAAAAUUAAAU | 25 | 15 |
| COL3A1_H15A(+20+44) | GGGGAUCCAGGGAAUCCGGCAGUUC | 25 | 15 |
| COL3A1_H15D(+6−19) | UAUAGAAACACAUGUUUACCUUAGC | 25 | 15 |
| COL3A1_H15A(+25+49) | CACCAGGGGAUCCAGGGAAUCCGGC | 25 | 15 |
| COL3A1_H15A(+15+39) | UCCAGGGAAUCCGGCAGUUCCAGGA | 25 | 15 |
| COL3A1_H15A(+20+39) | UCCAGGGAAUCCGGCAGUUC | 20 | 15 |
| COL3A1_H15A(+25+44) | GGGGAUCCAGGGAAUCCGGC | 20 | 15 |
| Control * | CCTCTTACCTCAGTTACAATTTATA | 25 | None |
* Control ASO targets an intron of the human beta-globin gene. This ASO was purchased from Genetools.