Figure 5.

Effect of exercise, genistein, and genistein + exercise combined on open-field behavioral testing in male mice. Quantification of the time the mice spent in lateral spaces and center areas with distance covered in each and average speed in each space. Controls, standard diet (Ln, open bars); high-fat high-sugar diet (HFHS, solid black bars); HFHS + exercise (Ex, horizontal line bars); HFHS + genistein (Gen, hashed bars); HFHS + genistein + exercise (Gen+Ex, gray bars). Data are means ± SEM (n = 4–5/group). * Denotes p < 0.05, statistical difference to lean controls.