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. 2024 Aug 8;25(16):8636. doi: 10.3390/ijms25168636

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the influence of the LC in chronic pain and its frequent comorbidities. The inner brown ring represents the intrinsic symptoms of chronic pain: Myofascial pain, aches, soreness, fatigue, allodynia, enhanced somatosensory perception, central sensitization, etc. The outer green ring represents the most frequent chronic pain comorbidities (clockwise → depression, sleep, and anxiety disorders) and the potential effects of the LC on each of them (blue dashed arrows). The existence of a common hub for at least a portion of chronic pain comorbidities will facilitate the development of adapted and individualized clinical responses. This figure was created using PowerPoint (version 16.87) and BioRender 2024.