Table 3.

5β-Steroid ligands that activate the human PXR ¹.

5β-Steroid	EC50 (μM)	% Efficacy/100
5β-pregnane-3,20-dione	2.6 ± 0.2	0.97
5β-pregnane-3α,20β-diol	3.81 ± 0.3	0.94
5β-androstan-3α-ol	1.41 ± 0.01	1.12
Lithocholic acid acetate	1.2 ± 0.2	0.54
Lithocholic acid	10.0 ± 0.1	0.15
7-Ketolithocholic acid	21.5 ± 1.4	0.58
12-Ketolithocholic acid	31.3 ± 5.8	0.86
Taurochenodeoxycholate	104 ± 0.8	0.5
5β-cholan-3α,7α,12α,24-tetrol	>100	0

¹ Taken from [82].