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. 2024 Aug 22;25(16):9115. doi: 10.3390/ijms25169115

Figure 5.

Figure 5

Characterization of the expression of SGN markers at 32 DIV in paradigm 2. (A) The differentiated SGN-like cells displayed a bipolar morphology and expressed a panel of SGN known markers such as SOX2 (green), BRN3A (red), TUJ1 (green), PRPH (red), and TRKC (red). A subset of these differentiated cells was double immunopositive for SOX2/BRN3A, characteristic of SGN phenotype. In addition, they express TRKC and PRPH which are also SGN-related markers. Scale bar = 100 µm. (B) The table represents the percentage of cells expressing SOX2, BRN3A, and SOX2/BNR3A. Cell count indicates about 40% of the differentiated cells at 32 DIV are double immunopositive for BRN3A/SOX2 from n = 2709 counted cells.