Figure 1.

CHD1Li synergizes with TNBC therapies in SUM149PT organoids. (A) Bliss synergy 3D plots showing synergy scores for each dose combination of OTI-611 (1.7–1.9 µM) and PARPi and SOC chemotherapy. (B) Dose–response matrices representing the percentage of cell death caused by OTI-611, PARPi and SOC therapy, and their combinations. (C) Dose–response curves showing OTI-611’s synergistic effect when combined with PARPi and SOC chemotherapy as measured by IC₅₀ values. SUM149PT organoids were treated with drug combinations for 72 h. Bliss synergy score values were calculated using the SynergyFinder R package version 3.12.0. To evaluate synergy, OTI-611 was treated at sub-lethal doses. Synergy score values above 10 are considered a synergistic interaction between drugs. Data are presented as the mean of two independent experiments ± S.E.M. See also Figures S2 and S3.