Table 2.

Comparison of the percentage or number of immunoregulatory cells in remission versus nonremission for different DAS28-score-based remission statuses.

Remission Statuses	Breg	Tr1	M2 Macrophages
DAS28-ESR < 2.6 (n = 98, remission) vs. ≥2.6 (n = 49, nonremission)	0.341	0.698	0.871
DAS28-CRP < 2.5 (n = 62, remission) vs. ≥2.5 (n = 84, nonremission)	0.503	0.983	0.983
SDAI ≤ 3.3 (n = 90, remission) vs. >3.3 (n = 56, nonremission)	0.461	0.374	0.342
DAS28-MCP-1 < 2.2 (n = 79, remission) vs. ≥2.2 (n = 68, nonremission)	0.542	0.269	0.036 *

DAS28: Disease Activity Score 28; SDAI: Simplified Disease Activity Index. p values are presented. Breg (immunoregulatory B cells) and Tr1 (T regulatory type 1 cells) were compared in terms of their percentages (%), and M2 macrophages were compared in terms of the number per milliliter (number/mL). The numbers behind the DAS28 scores denote the visit numbers. The comparison of M2 macrophage numbers between the DAS28-MCP-1 < 2.2 (n = 79 visits, median = 2000, 25% and 75% percentiles = 1000 and 4400) and DAS28-MCP-1 ≥ 2.2 (n = 68 visits, median = 3100, 25% and 75% percentiles = 1600 and 5675) groups through Mann–Whitney U test provided * p = 0.036. Detailed medium and 25–75% ranges of all data are given in Supplementary Table S2.