Table 6.
Correlation between immunoregulatory cells or cytokines and Total Ultrasound Scores in the ultrasound grade subgroups #.
| Items | Grade ≤ 1 (n = 89) | Grade > 1 (n = 58) | ||||
|---|---|---|---|---|---|---|
| Percentage | rho | p-Value | Percentage | rho | p-Value | |
| Breg | 58.2% | 0.044 | 0.684 | 41.8% | 0.207 | 0.118 |
| Tr1 | 59.9% | 0.242* | 0.022 * | 40.1% | −0.046 | 0.732 |
| M2 | 61.7% | 0.221 | 0.038 * | 38.3% | −0.155 | 0.246 |
| IL-4 | 59.4% | −0.026 | 0.809 | 40.6% | 0.167 | 0.209 |
| IL-5 | 50.8% | −0.297 | 0.005 * | 49.2% | −0.197 | 0.138 |
| IL-9 | 60.5% | −0.034 | 0.755 | 39.5% | 0.036 | 0.787 |
| IL-10 | 58.3% | −0.057 | 0.595 | 41.7% | 0.311 | 0.017 * |
| IL-13 | 60.5% | 0.074 | 0.492 | 39.5% | 0.144 | 0.282 |
| IL-27 | 60.5% | −0.051 | 0.638 | 39.5% | 0.017 | 0.901 |
| IL-35 | 60.5% | −0.08 | 0.454 | 39.5% | −0.23 | 0.082 |
| TGF-β1 | 58.6% | 0.045 | 0.721 | 41.4% | 0.286 | 0.071 |
| sTNF-R1 | 60.5% | 0.011 | 0.921 | 39.5% | 0.106 | 0.427 |
| sTNF-R2 | 60.5% | −0.206 | 0.053 | 39.5% | 0.067 | 0.618 |
# Ultrasound scoring system: see ref. [20]. Combined ultrasound groups: Grade ≤ 1, comprising grade 0 and grade 1; grade > 1, comprising grade 2 and grade 3. Total Ultrasound Scores: the sum of ultrasound grades for grayscale and power Doppler of all examined joints. Breg: immunoregulatory B cells; Tr1: T regulatory type 1 cells; M2: alternatively activated macrophages, M2 macrophages. All cytokines are expressed as pg/mL. Correlation was determined using Spearman’s correlation; * indicates statistical difference with p-values < 0.05.