Table 7.
Changes in different laboratory data and disease activity measures with Total Ultrasound Scores across three time points in the 12-month period.
| M0 (n = 50) | M6 (n = 49) | M12 (n = 48) | |
|---|---|---|---|
| CRP(mg/L) | 3.88 ± 4.24 (0.2–16.7) | 3.71 ± 6.05 (0.2–35.6) | 3.63 ± 6.09 (0.2–36.61) |
| ESR(mm/hr) | 13.86 ± 8.83 (2–39) | 15.88 ± 14.99 (2–74) | 16.45 ± 13.36 (3–65) |
| RF(IU/mL) | 73.97 ± 116.93 (8.38–512) | 56.16 ± 104.21 (5–456) | |
| Anti-CCP(CU) | 463.42 ± 631.56 (4.19–2776.7) | 396.22 ± 525.75 (4.6–1974) | |
| TJC | 0.54 ± 0.99 (0–4) | 0.96 ± 1.27 (0–6) | 1.15 ± 1.44 (0–6) |
| SJC | 0.22 ± 0.46 (0–2) | 0.45 ± 0.98 (0–4) | 0.46 ± 0.80 (0–4) |
| DAS28-ESR | 2.08 ± 0.72 (0.47–3.90) | 2.29 ± 0.75 (0.97–4.11) | 2.53 ± 0.92 (0.97–5.08) |
| DAS28-CRP | 2.60 ± 0.65 (1.38–4.08) | 2.77 ± 0.78 (1.38–4.42) | 2.93 ± 0.94 (1.38–5.52) |
| SDAI | 2.35 ± 3.36 (0.02–15.11) | 3.58 ± 4.27 (0.02–17.14) | 4.85 ± 5.76 (0.02–20.84) |
| DAS28-MCP-1 | 2.03 ± 0.65 (1.40–3.85) | 2.36 ± 0.73 (1.48–4.33) | 2.61 ± 0.77 (1.58–4.37) |
| HAQ-DI | 0.22 ± 0.46 (0–1) | 0.09 ± 0.32 (0–2) | 0.13 ± 0.30 (0–1.333) |
| Total Ultrasound Scores # | 6.62 ± 4.38 (0–18) | 5.63 ± 3.33 (1–17) | 5.35 ± 3.32 (0–16) |
| Breg cells (%) | 55.93 ± 11.92 (20.9–82.9) | 54.49 ± 12.22 (17.8–81.3) | 46.02 ± 15.04 (0.15–77.2) |
| Tr1 cells (%) | 12.70 ± 8.56 (0.00756–36.3) | 13.91 ± 8.83 (2.61–52.5) | 13.54 ± 10.58 (1.31–49.2) |
| M2 Macrophages (/mL) | 4838.00 ± 7748.97 (100–48,000) | 3467.35 ± 2524.91 (0–11,000) | 3547.92 ± 2848.52 (0–12,000) |
| IL-4 (pg/mL) | 33.56 ± 72.40 (0–427.32) | 23.05 ± 58.12 (0–327.69) | 21.20 ± 47.70 (0–298.40) |
| IL-5 (pg/mL) | 11.02 ± 42.24 (0–268.92) | 7.56 ± 28.97 (0–172.03) | 9.18 ± 36.68 (0–220.96) |
| IL-9 (pg/mL) | 55.32 ± 96.37 (0–446.44) | 52.85 ± 71.22 (0–379.22) | 50.09 ± 74.30 (0–376.99) |
| IL-10 (pg/mL) | 252.37 ± 1011.63 (0–7204.82) | 172.63 ± 779.45 (0–5411.55) | 177.78 ± 926.73 (0–6251.72) |
| IL-13 (pg/mL) | 604.86 ± 1004.64 (102.01–6992.33) | 451.60 ± 673.03 (99.56–4572.34) | 415.63 ± 770.28 (92.20–5269.50) |
| IL-27 (pg/mL) | 4240.43 ± 4456.56 (1037.52–15,929.04) | 3296.35 ± 3286.28 (1072.67–12,168.10) | 3527.30 ± 3297.42 (880.75–12,914.61) |
| IL-35 (pg/mL) | 957.05 ± 1768.78 (0–7426.85) | 929.91 ± 1443.46 (29.12–5921.65) | 716.11 ± 1144.05 (13.64–5091.10) |
| TGF-β1 (pg/mL) | 67.49 ± 29.71 (17.52–166.55) | 20.99 ± 15.84 (1.06–77.12) | 24.77 ± 13.88 (5.08–58.53) |
| sTNF-R1 (pg/mL) | 516.02 ± 258.30 (49.67–1336.79) | 462.02 ± 153.89 (153.35–880.48) | 480.21 ± 142.67 (183.20–820.89) |
| sTNF-R2 (pg/mL) | 972.47 ± 426.35 (109.76–1697.60) | 599.00 ± 105.35 (293.94–726.07) | 298.04 ± 161.95 (83.06–667.55) |
# The sum of ultrasound grades for grayscale and power Doppler scores of all examined joints. TJC: tender joint count; SJC: swollen joint count; DAS28: Disease Activity Score 28; SDAI: Simplified Disease Activity Index; HAQ-DI: Health Assessment Questionnaire-Disability Index; Breg: immunoregulatory B cells; Tr1: T regulatory type 1 cells; M2 macrophages: alternatively activated macrophages.