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. 2024 Aug 22;25(16):9092. doi: 10.3390/ijms25169092

Figure 3.

Figure 3

Effects of FK506 administration on hippocampal TauO levels and phosphorylation. Representative immunofluorescence images and relative quantification analyses of Tau (green), p-Tau (AT8-red), and their ratio in (a–d) dentate gyrus (DG), (e–h) CA1, and (i–l) CA3 of control mice (PBS + aCSF and FK506 + aCSF), mice ICV injected with TauO (PBS + TauO), and mice ICV injected with TauO and treated with Fk506 (FK506 + TauO). Original magnification (60×), scale bar (30 µm). Data represent the mean ± SEM; biological replicates n = 4 per group; one-way ANOVA with Tukey’s post hoc corrections for multiple comparison; * p < 0.05, ** p < 0.01, and *** p < 0.001.