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PXA increased CDDP-induced DNA damage and oxidative stress. (A) DNA damage levels in HCT116 and HT29 cells treated with PXA and CDDP for 24 h were assessed using the comet assay. Scale bars: 100 μm. (B) After 24 h of treating HCT116 and HT29 cells with PXA and CDDP, the content of GSH, SOD, and HO-1 was measured using ELISA. Results are expressed as means ± SD. * p < 0.05, ** p < 0.01 versus the control group, # p < 0.05, ## p < 0.01 versus the CDDP-treatment group.
