Figure 8.

Sub-toxic concentrations of the Skeletonema marinoi ethanol extract inhibit lipogenesis in SEBO662AR human sebocytes. Cultured cells were exposed to increasing concentrations of Skeletonema marinoi ethanol extract, within a low toxicity range (1–10 µg·mL⁻¹) and lipogenesis was assessed using a BODIPY^® 493/503 probe. The lipogenesis inhibitors cerulenin 10 µM and dutasteride 10 µM respectively induced a highly and extremely significant inhibition of lipogenesis, as compared to control conditions. The Skm ethanol extract induced a highly significant lipogenesis inhibition at 5 µg·mL⁻¹ and extremely significant inhibition at 10 µg·mL⁻¹. p value: ns ≥ 0.05, not significant; ** = 0.001 to 0.01, highly significant; *** ≤ 0.001, extremely significant.