Table 1.
Summative table with subjects and data analyses.
| No. | Maternal Age | Paternal Age | History | Ultrasonography | CLP | Weeks of Pregnancy | Fetal Karyotype | CLP Heterogenity Linked to Fetal Karyotype and Pedigree Analysis | Genetic Component of CLPs | Observation |
|---|---|---|---|---|---|---|---|---|---|---|
| 1. | 24 | 26 | first pregnancy | female monofetal pregnancy | UCLR | 31.3 | 46, XX | isolated, sporadic, non-hereditary case |
non-syndromic case | second opinion confirmed postnatally |
| 2. | 26 | 30 | first pregnancy | male monofetal pregnancy intrauterine growth restriction, left equinovarus |
UCLPL | 23.1 | 46 XY, t(7;16) (p14;p11.) | isolated, sporadic, syndromic, non-hereditary case | translocation syndrome |
termination of pregnancy, confirmed by fetal autopsy |
| 3. | 31 | 51 | first pregnancy | male monofetal pregnancy, nuchal translucency, spina bifida, and congenital heart anomaly with moderate regurgitation of the tricuspid valve | UCPLR | 17 | 46, XY | isolated, sporadic, non-hereditary case |
non-syndromic case | termination of pregnancy, confirmed by fetal autopsy |
| 4. | 26 | 32 | first pregnancy | male monofetal pregnancy, oligohydramnios, hypoplastic nasal bone, bilateral polycystic kidney and intrauterine growth restriction | BCLP | 20 | 46, XY/47, XY, +13 | isolated, sporadic, syndromic, non-hereditary case | Patau syndrome, mosaic trisomy 13 |
termination of pregnancy, confirmed by fetal autopsy |
| 5. | 31 | 37 | second pregnancy | male monofetal pregnancy, ventricular septal defect | UCLPR | 20 | 47, XY, +13 | isolated, sporadic, syndromic, non-hereditary case | Patau syndrome, trisomy 13 | termination of pregnancy, confirmed by fetal autopsy |
| 6. | 29 | 27 | first pregnancy | female monofetal pregnancy, ocular hypertelorism, polycystic kidney and polydactyly | UCLPR | 25 | 46, XX/47, XX, +13 | isolated, sporadic, syndromic, non-hereditary case |
Patau syndrome, mosaic trisomy 13 | termination of pregnancy confirmed by fetal autopsy |
| 7. | 39 | 45 | first pregnancy | male monofetal pregnancy, hypoplastic nasal bone, agenesis of the corpus callosum and ventriculomegaly | UCLPL | 19 | 46, XY | isolated, sporadic, non-hereditary case |
non-syndromic case | termination of pregnancy confirmed by fetal autopsy |
| 8. | 31 | 34 | first pregnancy | female monofetal | UCLR | 31.6 | 46, XX | isolated, sporadic, non-hereditary case |
non-syndromic case | second opinion, confirmed postnatally |
| 9. | 27 | 30 | second pregnancy | female monofetal pregnancy, microcephaly | UCLPR | 19 | 46, XX/47, XX, +13 | isolated, sporadic, syndromic, non-hereditary case | Patau syndrome, mosaic trisomy 13 | termination of pregnancy, confirmed by fetal autopsy |
| 10. | 29 | 33 | second pregnancy | male monofetal pregnancy, equinovarus | UCLPR | 20 | 46, XY | isolated, sporadic, non-hereditary case |
non-syndromic case | termination of pregnancy, confirmed by fetal autopsy |
| 11. | 38 | 45 | first pregnancy | male monofetal pregnancy, lax nuchal cord | UCLL | 20 | 46, XY | isolated, sporadic, non-hereditary case |
non-syndromic case | termination of pregnancy confirmed by fetal autopsy |
| 12. | 24 | 30 | first pregnancy | female monofetal pregnancy, moderate gastric distension | UCLL | 23 | 46, XX | isolated, sporadic, non-hereditary case |
non-syndromic case | second opinion, confirmed postnatally |
| 13. | 36 | 42 | first pregnancy | male monofetal pregnancy, ventriculomegaly | UCLPR | 18 | 47, XY, +13 | isolated, sporadic, syndromic, non-hereditary case | Patau syndrome, trisomy 13 | termination of pregnancy confirmed by fetal autopsy |
| 14. | 26 | 32 | first pregnancy | male monofetal pregnancy, ventriculomegaly | UCLPL | 19 | 47, XY, +13 | isolated, sporadic, syndromic, non-hereditary case | Patau syndrome, trisomy 13 | termination of pregnancy confirmed by fetal autopsy |
| 15. | 41 | 50 | second pregnancy | male monofetal pregnancy, retrognathia, moderate micrognathia, hemi ventriculomegaly, suspicion of lissencephaly | UCLPR | 18 | 46, XY/47, XY, +18 | isolated, sporadic, syndromic, non-hereditary case | Edwards syndrome, mosaic trisomy 18 | termination of pregnancy confirmed by fetal autopsy |
| 16. | 28 | 40 | first pregnancy | female monofetal pregnancy, coarctation of the aorta | UCLPL | 17 | 46, XX | isolated, sporadic, non-hereditary case | non-syndromic case | termination of pregnancy confirmed by fetal autopsy |
| 17 | 23 | 31 | first pregnancy | male monofetal pregnancy, Spalding sign, double cranial contour, developmental arrest | UCLPL | 19 | 47, XY, +13 | isolated, sporadic, syndromic, non-hereditary case | Patau syndrome, trisomy 13 | termination of pregnancy confirmed by fetal autopsy |
Unilateral cleft lip right (UCLR), Cleft palate with unilateral cleft lip left (UCLPL), Cleft palate with unilateral cleft lip right (UCLPR), Bilateral cleft lip and palate (BCLP), Unilateral cleft lip left (UCLL).