Fig 5. Effect of seizure offset pattern on HPC/SN activity.

Example of typical ARR (A), RHY (B) and BS (C) seizure offset pattern. (D) Percentage of ARR, RHY, BS and undetermined seizures for NHP 1 and 2. (E) Changes in the averaged SN power and (F) HPC-SN coherence for LAF and HAS seizures. Results are mean ± SEM. Statistical comparison for comparison of offset and post-ictal period was performed with a Wilcoxon signed rank test, *<0.05, **<0.01, ***<0.001. Comparisons between ARR, RHY and BS seizures were performed with an ANOVA and Dunn’s Post hoc test, # <0.05, ##<0.01. Statistical values were corrected for multiple comparison using the Bonferroni method.