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sTYR and sPHE changes across visits over four years are shown in NAC, SN2 N−, and SN2 N+. Note the use of Y-axis breaks. Statistical significance of differences across visits within each group (NAC or SN2 N− or SN2 N+) are indicated by *, **, ***and ****, representing p < 0.05, 0.01, 0.001, and 0.0001, respectively.
