Table 2.
Moderated mediation model of household enteric pathogen transmission pathways and HAZ at 60-day follow-up among 620 children 0–11 months of age in the MSD cohort in Kolkata, India.
| Dependent Variable | Independent Variable | Path Coefficient | 95% CI 1 | One Tailed p-Value |
|---|---|---|---|---|
| HAZ (60 days) 2 | Rotavirus | −0.06 | (−0.12, −0.02) | 0.02 |
| Typical EPEC | −0.14 | (−0.21, −0.01) | 0.01 | |
| Shared sanitation facilities | −0.13 | (−0.19, −0.04) | <0.01 | |
| Water sourced from deep well | −0.06 | (−0.22, 0.16) | 0.31 | |
| Water stored | 0.13 | (−0.12, 0.15) | 0.41 | |
| Hands washed before nursing | 0.14 | (0.03, 0.22) | <0.01 | |
| Hands washed before cooking | −0.21 | (−0.13, 0.08) | 0.36 | |
| Rotavirus | Water stored | 0.62 | (0.35, 1.10) | <0.01 |
| Hands washed after caretaker defecation | −0.36 | (−0.62, −0.14) | <0.01 | |
| Hands washed before cooking | −0.76 | (−1.12, −0.50) | <0.01 | |
| Use of soap | 0.06 | (−0.16, 0.28) | 0.30 | |
| Typical EPEC | Hands washed after caretaker defecation | −0.55 | (−0.91, −0.11) | <0.01 |
| Indirect effects of household reservoirs and hygiene behaviors 3 | ||||
| Water storage mediated by rotavirus infections | −0.03 | (−0.10, −0.01) | 0.02 | |
| Handwashing after defecation mediated by rotavirus | 0.02 | (0.01, 0.06) | 0.02 | |
| Handwashing before cooking mediated by rotavirus | 0.04 | (0.01, 0.10) | 0.02 | |
| Handwashing after defecation mediated by tEPEC | 0.07 | (0.01, 0.15) | 0.02 | |
1 Bayesian credibility interval. 2 Child’s age, sex, breastfeeding status at baseline, baseline HAZ and length of follow-up included in pathway. 3 Indirect effects represent pathogen-specific transmission pathways leading to children’s exposure to enteric infections and growth impairment. Indirect effects calculated by multiplying coefficients for paths a × b in Figure 2A–C. Model included age, sex of child, HAZ at baseline and duration of time until follow-up.