Figure 3.
Effect of intraperitoneal treatment with 17-DMAG in different therapeutic regimens on the development of lesions in mice infected with L. braziliensis. BALB/c mice were infected in the ear with 105 promastigotes of L. braziliensis in the stationary phase. After two weeks of infection, mice were treated intraperitoneally with 17-DMAG at doses of 20 mg/kg daily (n = 6), 30 mg/kg every two days (n = 6), or 50 mg/kg every five days (n = 6). Untreated control animals received 5% glucose solution every day intraperitoneally. (A) Graph depicts the difference of thickness in mm (Δ OE-OD) measured from the infected ear compared to the contralateral ear over four weeks of treatment; (B) area under the curve (AUC) of the thickness of the lesions shown in (A). One-way ANOVA test, * p < 0.05; ** p < 0.005; **** p < 0.0001.