Figure 9.

Macroscopic aspect of lesions in the ear and of lymph nodes from BALB/c mice infected with L. braziliensis intraperitoneally treated with 17-DMAG at early time points of treatment. BALB/c mice were infected in the ear with 5 × 10⁵ metacyclic form of L. braziliensis promastigotes. After two weeks of infection, animals were treated with 20 mg/kg/day of 17-DMAG for 2, 4, 7, 14, or 28 days (K–T). Control mice received 5% glucose solution intraperitoneally during the same time points (A–J). Images represent lesions (A,C,E,G,I) and lymph nodes (B,D,F,H,J) of BALB/c mice infected or infected and treated (lesions: (K,M,O,Q,S); lymph nodes: (L,N,P,R,T)). Animal lesions were measured from 2 to 7 days, then once a week, and ear sizes were expressed as the difference between the thickness of infected ears and contralateral ears after 2 (U), 4 (V), 7 (W), 14 (X), or 28 (Y) days of treatment. Unpaired t test, * p < 0.05; ** p < 0.01.