Table 5.
Characteristics of some methods reported for the determination of thymol and carvacrol in the literature to be compared with the developed technique.
| Method | Solvent | Analyte | LOD (mg mL−1) |
R2 | Linear Range (mg mL−1) |
tR g (min) | RSD h % | Recovery % |
Ref |
|---|---|---|---|---|---|---|---|---|---|
| HD-HSME-GC-FID a | Tetradecane, Pentadecane, Hexadecane, Heptadecane |
Thymol | 1.9 × 10−3 | 0.9944 | 6.2 × 10−3–8.1 × 10−2 | <20 | 6.4 | 89–101 | [4] |
| Carvacrol | 2.3 × 10−4 | 0.9979 | 1.2 × 10−3–8.8 × 10−2 | <20 | 11.4 | 95–116 | |||
| UAME-NMSPD-HPLC b | Acetonitrile Methanol |
Thymol | 2.3 × 10−7 | 0.9995 | 0.5 × 10−5–2.0 × 10−3 | - | 2.1–4.8 | 95–99 | [16] |
| Carvacrol | 2.1 × 10−7 | 0.9993 | 0.5 × 10−5–2.0 × 10−3 | - | 2.7–4.9 | 94–98 | |||
| HS-SPME-GC-MS c | Methanol | Thymol | 8.9 × 10−7 | 0.9994 | 2.0 × 10−6–4.0 × 10−4 | <7 | 2.2–11.3 | - | [42] |
| Carvacrol | 5.7 × 10−7 | 0.9997 | 2.0 × 10−6–4.0 × 10−4 | <7 | 0.8–9.8 | - | |||
| VASE-DLLME- HPLC d | Chloroform Acetonitrile |
Thymol | 1.6 × 10−6 | 0.9998 | 0.5 × 10−5–4.0 × 10−3 | <14 | 1.0–4.8 | 97 | [11] |
| Carvacrol | 1.6 × 10−6 | 0.9998 | 0.5 × 10−5–4.0 × 10−3 | <14 | 1.0–4.8 | 97 | |||
| MMIP-DSPME- HPLC e | Acetonitrile | Thymol | (0.4–1.0) × 10−5 | 0.999 | 0.4 × 10−6–5.0 × 10−2 | <7 | 1.0–4.9 | 97–104 | [15] |
| Carvacrol | (0.4–1.0) × 10−5 | 0.999 | 0.4 × 10−6–5.0 × 10−2 | <7 | 1.7–6.3 | 97–105 | |||
| DLLME-SFO-GC-FID f | Undecanol | Thymol | 9.5 × 10−4 | 0.9939 | (0.3–7.0) × 10−2 | 14.9 | 2.7 | 96–98 | [This work] |
| Carvacrol | 8.9 × 10−4 | 0.9995 | (0.3–7.0) × 10−2 | 15.2 | 2.6 | 94–101 |
a Hydro distillation-headspace solvent microextraction gas chromatography-flame ionization detector. b Ultrasound-assisted microextraction-nano material solid phase dispersion high-performance liquid chromatography. c Headspace solid-phase microextraction gas chromatography-mass spectrometry. d Vortex-assisted surfactant-enhanced dispersive liquid–liquid microextraction high-performance liquid chromatography. e Nano-sized magnetic molecularly imprinted polymer-dispersive solid phase microextraction-high performance liquid chromatography. f Ultrasound-assisted dispersive liquid–liquid microextraction by solidifying floating organic droplets gas chromatography-flame ionization detector. g Retention time. h Relative standard deviation.