Table 2.
Plasma isoflavone concentration in nmol/L of juvenile (21 days) female DUC, DUhTP, and DU6 mice that received diet A, S, or SPA. Statistical analysis was performed using two-way ANOVA. Significant differences between strains compared to the DUC and DUhTP line are marked with # and §. Significant differences between chow groups are marked with letters. For abbreviations, see Figure 1; additional abbreviations: n.d.—not detected/below quantitation limit; G—glucuronide; S—sulfate.
| Juvenile Females |
Line | DUC | DUhTP | DU6 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Diet Count |
A n = 8 |
S n = 8 |
SPA n = 6 |
A n = 8 |
S n = 8 |
SPA n = 6 |
A n = 8 |
S n = 8 |
SPA n = 8 |
|
| Total Isoflavones |
mean | 2475.3 a | 1939.8 a | 4.8 b | 4086.1 #a | 2291.1 b | 1.5 c | 5822.8 #§a | 4300.6 #§b | n.d. c |
| SD | 1142.5 | 746.1 | 8.8 | 666.4 | 510.7 | 2.3 | 1573.2 | 1464.1 | ||
| Total Daidzein Equivalents | mean | 952.3 a | 656.5 a | 2.4 b | 1689.3 a | 745.8 b | 1.5 c | 2542.9 #a | 1241.8 #§b | n.d. c |
| SD | 809.2 | 309.9 | 4.1 | 365.0 | 163.3 | 2.3 | 1219.0 | 291.8 | ||
| Daidzein (free Aglycone) |
mean | 183.0 a | 102.7 a | n.d. b | 215.7 a | 73.7 b | n.d. c | 574.1 #§a | 229.5 #§b | n.d. c |
| SD | 154.1 | 54.2 | 74.9 | 22.5 | 195.3 | 41.9 | ||||
| Total Genistein Equivalents | mean | 718.2 a | 488.5 a,b | 2.0 b | 1353.9 #a | 564.0 b | n.d. c | 2550.5 #§a | 1183.1 #§b | n.d. c |
| SD | 560.7 | 243.3 | 4.9 | 546.0 | 148.3 | 787.0 | 507.1 | |||
| Genistein (free Aglycone) |
mean | 74.5 a | 40.8 a,b | n.d. b | 102.0 a | 28.4 b | n.d. b | 307.5 #§a | 127.8 #§b | n.d. c |
| SD | 56.2 | 23.5 | 65.0 | 10.4 | 83.3 | 74.3 | ||||
| Sum of Equol, Equol-7-G and Equol-4′-S | mean | 804.9 a | 794.9 a | 1.5 b | 1042.9 a | 981.3 a | 0.3 b | 1036.9 a | 2003.6 #§b | n.d. c |
| SD | 640.2 | 281.9 | 3.1 | 237.0 | 300.2 | 0.8 | 729.5 | 1179.6 | ||