Table 5.
Plasma isoflavone concentration in nmol/L of adult (DOP 4) DUC, DUhTP, and DU6 females that received diet A, S, or SPA. Statistical analysis was performed using two-way ANOVA. Significant differences between strains compared to the DUC and DUhTP lines are marked with # and §. Significant differences between chow groups are marked with letters. For abbreviations, see Figure 1. Additional abbreviations: SD—standard derivation; G—glucuronide; S—sulfate.
| Adult Females |
Line | DUC | DUhTP | DU6 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Diet Count |
A n = 13 |
S n = 11 |
SPA n = 11 |
A n = 13 |
S n = 14 |
SPA n = 11 |
A n = 10 |
S n = 11 |
SPA n = 6 |
|
| Total Isoflavone |
mean | 3541.7 a | 3075.2 a | 10.6 b | 3619.2 a | 2322.9 a | 4.5 b | 6738.4 #§a | 3448.4 b | 0.6 c |
| SD | 875.1 | 1066.2 | 15.7 | 752.0 | 1165.4 | 6.3 | 2918.1 | 1259.6 | 1.0 | |
| Total Daidzein Equivalents |
mean | 846.6 a | 830.8 a | 4.6 b | 1342.1 #a | 703.5 b | 2.4 c | 1548.4 #a | 852.8 b | 0.0 c |
| SD | 248.7 | 395.0 | 7.8 | 515.7 | 413.1 | 2.3 | 550.5 | 272.9 | 0.0 | |
| Daidzein (free Aglycone) |
mean | 119.6 a | 107.2 a | 0.0 b | 78.0 a | 36.6 a | 0.4 a | 316.0 #§a | 170.2 §b | 0.0 c |
| SD | 46.4 | 63.0 | 0.0 | 37.0 | 18.6 | 1.4 | 127.1 | 63.2 | 0.0 | |
| Total Genistein Equivalents | mean | 841.1 a | 997.0 a | 2.7 b | 1096.1 a | 655.6 a,b | 1.0 b | 2566.0 #§a | 966.2 b | 0.0 c |
| SD | 226.1 | 479.6 | 4.9 | 354.3 | 390.3 | 2.3 | 1698.0 | 468.0 | 0.0 | |
| Genistein (free Aglycone) | mean | 35.0 a | 35.4 a | 0.1 b | 24.3 a | 13.2 a | 0.5 a | 127.1 #§a | 55.8 §b | 0.3 c |
| SD | 11.1 | 19.3 | 0.5 | 10.4 | 6.9 | 1.6 | 44.7 | 27.9 | 0.7 | |
| Sum of Equol, Equol-7-G, and Equol-4′-S | mean | 1602.6 a | 1104.8 a | 3.2 b | 1078.6 a | 914.0 a | 0.2 b | 2181.2 §a | 1403.5 b | 0.4 c |
| SD | 600.0 | 499.5 | 5.4 | 317.0 | 382.9 | 0.7 | 1068.4 | 794.7 | 0.9 | |