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Hypnotic effect of ESK in a pentobarbital-induced sleep model. (A) Sleep onset latency and (B) total sleep time. ESK (3, 10, 30 mg/kg, p.o.) and diazepam (1 mg/kg, p.o.) were administered 30 min before pentobarbital (45 mg/kg, i.p.) administration. Data are presented as Mean ± SEM (n ≥ 5). * p < 0.05 vs. CTL. CTL, control; DZP, diazepam.
