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. 2024 Aug 16;17(8):1080. doi: 10.3390/ph17081080

Figure 2.

Figure 2

Vorinostat-dependent growth inhibition in MKN-74, MKN-45, and Hs746T cells. (A) Determination of viable cells after 48 h treatment with 5 µM vorinostat and/or 5 mM NAC as compared to vehicle (DMSO) control. (B) Effects of a lower vorinostat concentration (1 µM) on cell growth over 5 days and its modulation by NAC in MKN-45 cells. Of note, 25,000 cells in a 12-well format were used for the short-term incubation (A) and 750 cells in a 96-well format were used for the long-term incubation (B), which also affects the susceptibility of the cells to the treatment. Cell viability was determined using the formazan-based CCK8 assay. Each bar or point in the diagram represents the mean of at least three independent experiments + SEM. **, p < 0.01 and ***, p < 0.001.