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. 2024 Aug 16;17(8):1080. doi: 10.3390/ph17081080

Figure 5.

Figure 5

(A) RT-qPCR analysis of mRNA levels of Nrf2 target genes in MKN-45, Hs746T, and MKN-74 cells, treated with 3 µM vorinostat (grey) vs. DMSO (black) for 48 h. (B) Vorinostat effects on the mRNA levels of the Nrf2 regulator Keap1 in the three cell lines. Expression levels of the respective gene were normalized to beta-actin as the housekeeping gene, and the relative expression levels of vehicle (DMSO)-treated cells were set to 1. Mean values of three independent experiments + SEM are shown. *, p < 0.05; **, p < 0.01 and ***, p < 0.001.