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(A) Proteomics analyses of vorinostat vs. DMSO treated MKN-45 cells. Expression pattern alterations of various Nrf2 regulators such as Keap1, p21 (CDKN1A), p62 (SQSTM1), and DPP3, as well as of Nrf2 target genes, are shown. Lower panel: group association of altered genes to different biochemical/cellular functions. (B) Schematic overview of the complex and multimodal pattern of HDACi effects on Nrf2 levels and activity.
