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. 2022 Nov 17;1(11):1072–1083. doi: 10.1038/s44161-022-00140-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, mRNA expression levels of Csrp3 in various mouse organs were assessed using real-time qPCR (n = 3 at each organ). Data are shown as mean ± SD. b, Design of shCsrp3 knockdown vector. Each shRNA was designed using ‘The RNAi consortium database’ (by Broad Institute) and #1 was chosen in this study. c, Images of Egfp expression within heart sections collected 1 week, 2 weeks, and 3 weeks after injection of AAV9-Egfp. This experiments were independently repeated two times to confirm that the similar expression level of Egfp were observed. d, Relative Csrp3 expression levels in the hearts of each group (control, AAV9-shCsrp3, and AAV9-Csrp3). e, Survival curves comparing Control (n = 13), AAV9-shCsrp3 injected mice (n = 5), and AAV9-Csrp3 injected mice (n = 5) after MI surgery. P = 0.0045; statistical analysis was performed using the Gehan–Breslow–Wilcoxon test.