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. 2022 Feb 17;1(2):157–173. doi: 10.1038/s44161-022-00018-8

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Gene based expression levels in mouse and human heart tissues performed to evaluate the impact of the size difference between positive and negative gene groups. Expression levels in known CHD genes added at all three stages for reference. Known CHD genes, however, showed significantly increased expression levels compared with positive mouse genes at all three stages. This analysis was further expanded to human heart tissue for genes with a mouse-human orthologue and presented a similar picture. Mean expression levels per groups compared using a Wilcoxon rank-sum test. X-axis denotes the gene groups evaluated; y-axis denotes the log-transformed mean expression in heart. The analysis was stratified by procedure (ECG and TTE) and developmental stages (development, maturation and postnatal). Data shown as mean, minimum, maximum and lower/upper quartiles. a. Expression analysis in mouse heart for ECG genes; b. Expression analysis in mouse heart for TTE genes. Note: RPKM, Reads per kilobase of transcript per Million mapped reads. c. Expression analysis in human heart for ECG genes; d. Expression analysis in human heart for TTE genes. Distribution of the mean expression in mouse heart differences between P and N genes. The negative gene group (higher number of genes) randomly down sampled to generate equal-size subgroups compared to the positive group. P-values denote the probability of observing by chance higher averaged expression level in negative group compared to positive group, in 50,000 permutations. The analysis stratified by procedure (e. ECG and f. TTE) and developmental stages (development, maturation and postnatal. Distribution of the mean expression in human heart differences between P and N genes. g. ECG and h. TTE and developmental stages (development, maturation and postnatal.