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. 2023 Jul 13;2(7):645–655. doi: 10.1038/s44161-023-00296-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, LVEF of mice undergoing isoflurane narcosis 30 min after the administration of NaCl (n = 6), ascending doses of EPI (EPI 2 mg kg⁻¹, n = 6; EPI 2.5 mg kg⁻¹, n = 10; EPI 5 mg kg⁻¹, n = 8) or isoprenaline (ISO) 250 mg kg⁻¹ (n = 8) (*P = 0.01). ns, not significant. b, Seven-day mortality with number of deceased given within bars (NaCl, n = 6; EPI 2 mg kg⁻¹, n = 6; EPI 2.5 mg kg⁻¹, n = 10; EPI 5 mg kg⁻¹, n = 8; ISO 250 mg kg⁻¹, n = 8). c, Model criteria. d, Percentage of surviving mice meeting criteria with number of mice given within bars (NaCl, n = 6; EPI 2 mg kg⁻¹, n = 6; EPI 2.5 mg kg⁻¹, n = 10; EPI 5 mg kg⁻¹, n = 8; ISO 250 mg kg⁻¹, n = 8). e,f, Echocardiography-derived left ventricular stroke volume (**P = 0.004) (e) and left ventricular end-systolic diameter (LVESD) timecourse (*P = 0.04) (NaCl, n = 5; EPI, n = 10) (f). g, Basal (base), midventricular (mid) and apical (apex) radial strain (NaCl, n = 5; EPI, n = 7; EPI base versus apex *P = 0.03, ***P = 0.0004). h, Kinetics of systolic and diastolic blood pressure (n = 3 in each group, *P = 0.03). i, ST-segment elevation and R-wave amplitude changes after EPI (n = 5 in each group). All mice were male and aged 8–10 weeks. Data expressed as mean ± s.e.m., from multiple comparisons adjusted ANOVA, two-sided t-test (h), two-sided paired t-test (15 min–7 d) (e) and one-tailed paired t-test (15 min–2 h) (f).

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