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. 2023 Jul 13;2(7):645–655. doi: 10.1038/s44161-023-00296-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — We observed impaired outcomes in male compared to female mice, including mortality (†), reduction of LVEF and plasma TnT, with marked myocardial calcineurin activation and inflammation. Apical contractility was particularly blunted after EPI with elevated endsystolic left ventricular diameter, mimicking apical ballooning (dashed lines and arrows). Calcineurin inhibition by CsA or FK506 reduces the takotsubo phenotype in male and female mice. α/β-AR, α- or β-adrenergic receptor