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. 2024 Apr 26;20(9):1199–1209. doi: 10.1038/s41589-024-01609-1

Extended Data Fig. 3. Time-evolved SAXS parameters for non-reproducing and non-dimerizing hits.

Extended Data Fig. 3

(a) Plots of time-evolved I(0) and Rg values for non-reproducing hits B2, B4, B6, B9, B10, and B12 compared to AIF-DMSO (red circles) and AIF-NADHDMSO controls (blue circles). Errors bars for AIF-DMSO represent the standard deviation of 2 independent replicates; error bars for AIF-NADHDMSO represent the standard deviation of 3 independent replicates. (b) Plots of time-evolved I(0) and Rg values for SAXS chemotype clusters CX3 (pink) and CX4 (red) compared to AIF-DMSO (red circles) and AIF-NADH-DMSO (blue circles) controls. Errors bars for AIF-DMSO represent the standard deviation of 2 independent replicates; error bars for AIF-NADH-DMSO represent the standard deviation of 3 independent replicates.

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