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. 2023 Sep 28;2(10):917–936. doi: 10.1038/s44161-023-00338-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Experimental design for the hemodynamic and transcriptomic characterization of RV samples in control (normal), compensated and decompensated states from rats subjected to PAB. b, PC analysis was performed on normalized RNA-seq data to visualize the gene expression profiles of all the RV samples. Control RV samples are shown in purple, compensated RV samples in green, and decompensated RV samples in orange. c–e, Volcano plots show the significance of each expressed gene (−log₁₀ FDR values on the y axis), plotted against the logarithmic fold change (log₂FC values on the x axis), in each pair of comparisons. DEGs were identified by DESeq2 (base mean expression ≥ 5; −0.585 ≤ log₂FC ≥ 0.585; FDR ≤ 0.05). (c) Compensated (blue) versus control RV (red) (c), decompensated (blue) versus control RV (red) (d) and decompensated (blue) versus compensated RV (red) (e). f–h, Top selected differentially enriched pathways for each pair of comparisons. Compensated versus control RV (f), decompensated versus control RV (g) and decompensated versus compensated RV (h). The dashed line shows FDR = 0.05.