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. 2023 Sep 28;2(10):917–936. doi: 10.1038/s44161-023-00338-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — Hemodynamic data collected by closed-chest right heart catheterization. RV hypertrophy was calculated as Fulton index (weight ratio of RV and (LV + septum)). (a) RV systolic pressure (RVSP), (b) total pulmonary resistance (TPR) (c) RV hypertrophy, (d) RV end-diastolic pressure (RVEDP), (e) cardiac output (CO). (f) Stroke volume (SV). Number of samples (n) in each group of comparison= 10. (g) Representative images of RV stained with Masson’s trichrome from control and MCT-treated rats with compensated RV (cRV) and decompensated RV (dRV) states. (h) Quantification of cardiac fibrosis in the same rat samples. (i) Representative images of RVs stained with H&E from control and MCT-treated rats. (j) Quantification of cardiomyocyte cross-sectional area (CSA) representing cardiomyocyte hypertrophy (from the same rat samples). (h, j) n(control)=4, n(compensated) = 9, n(decompensated)=9. Data are presented as mean ± SEM. (P value has been calculated by one-way ANOVA followed by Tukey’s multiple comparisons test). In all the box plots: Central bands represents 50% quantile (median), box interquartile ranges: 25–75%, and whiskers set to max/min, 1.5 IQR above/below the box.

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