Fig. 4.

Spearman’s correlation suggested that (A) neutralizing antibodies did not correlate with IgE levels after COVID-19 (n = 17 pairs) but correlated strongly with (B) IgE levels after two doses of vaccine (n = 30 pairs) and with (C) IgE avidity (n = 13 pairs). NAbs indexes were first reported in Silva et al. (reference 18) and were replotted in this manuscript for correlation analysis. Given that not all samples studied here had matched NAbs results, number of pairs is lower than the n assayed in other experiments, and ChAd, ChAd-cov, Corona and Corona-cov groups were pooled together for analysis, to yield more statistical power. These data was obtained using a surrogate neutralization assay based on an inhibition ELISA (cPass SARS-CoV-2 Neutralization Antibody Detection Kit, GenScript), which measures the capacity of a sera sample to inhibit RBD and ACE-2 binding.